Associate Scientist (BS/MS) contractor – Lentiviral Vector Research & Early Process Development (100% Bench)

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Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.

Associate Scientist (BS/MS) contractor – Lentiviral Vector Research & Early Process Development (100% Bench)

Contract Duration: One year

Why this matters:

This role accelerates cell and genome therapy research by enabling reliable generation, characterization, and improvement of lentiviral vectors used in discovery and preclinical studies.

The Opportunity

We are seeking a highly motivated Senior Research Associate / Associate Scientist (BS/MS) to advance lentiviral vector research with some early process development. This is a 100% bench-based, hands-on laboratory role focused on running, troubleshooting, and improving upstream and downstream LVV workflows to enable discovery and preclinical studies.

Key Responsibilities

• Scope note: this is a hands-on lab role and is not primarily computational, project-management, or supervisory.

• Design and execute iterative LVV experiments in adherent and/or suspension HEK293T-based systems (cell expansion, transfection, harvest, and in-process sampling) to evaluate and improve performance.

• Execute and optimize downstream processing, including clarification/filtration and concentration/buffer exchange using TFF/UF-DF; assess recovery, scalability, and robustness.

• Support early scale-up/scale-down studies (e.g., shake flasks, cell factories, wave or single-use stirred-tank bioreactors), including setup, sterile connections, sampling plans, and data-driven comparisons across scales.

• Quantify and interpret vector yield and quality using standard assays (e.g., qPCR/ddPCR titers, p24/ELISA, infectivity/functional readouts as applicable); communicate findings, hypotheses, and recommended next experiments.

• Maintain rigorous documentation in an electronic lab notebook (ELN) and author/refresh protocols and SOPs that improve reproducibility, safety, and throughput for R&D and early PD workflows.

• Collaborate with scientists to prioritize experiments, troubleshoot process/assay issues, and ensure safe handling of viral vectors and human-derived materials in accordance with BSL-2/EHS requirements.

Qualifications

• Minimum Qualifications

• B.S. with 4+ years, or M.S. with 2+ years of relevant industry or academic experience in molecular biology, bioengineering, cell biology, biochemistry, or related field.

• Demonstrated hands-on experience producing and concentrating viral vectors and/or biologics; familiarity with at least one downstream method (TFF/UF-DF, chromatography, or ultracentrifugation).

• Expertise in mammalian cell culture (aseptic technique, cell counting/viability, expansion, banking) with comfort working in BSL-2 environments.

• Ability to execute experiments with minimal supervision, troubleshoot process/assay issues, and communicate results clearly in a fast-paced R&D environment.

• Must be comfortable spending the majority of work time performing hands-on, bench-level laboratory work (e.g., tissue culture, transfection, purification/TFF, and assays).

• Strong documentation skills using ELNs (e.g., Benchling) and proficiency with standard data tools (Excel/GraphPad or equivalent).

• Able to work effectively both independently and collaboratively, with strong planning, organization, and cross-functional communication.

• Preferred Qualifications

• Experience with scalable unit operations for viral vector production (single-use stirred-tank or wave bioreactors, cell factories, TFF/UF-DF) and associated sampling/monitoring.

This role is open to individual contractors only. Recruitment agencies: please do not contact us or submit candidates.

Hourly Pay
$53—$74 USD

Adicet fosters a collaborative, high-performing environment by prioritizing in-person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.

At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting autoimmune diseases and cancer.

We offer a competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match.

To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs.

We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time-off including 13 company holidays, paid end-of-year winter break, vacation, sick time, and paid parental leave.

Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company-subsidized lunches (delivered onsite daily) and fully stocked breakrooms.

Adicet is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.