Associate Director / Director, Accounting and SEC Reporting

Role Summary

Reporting to Lexeo’s Vice President and Corporate Controller, the Director, Accounting, will be responsible for the overall accounting and SEC reporting activities of the Company in addition to driving process improvements and support of accounting policies, procedures and internal controls. This hands-on role will oversee a team of two, execute day-to-day accounting functions, and produce high-quality SEC reporting while ensuring the application of best practices and compliance with all policies and internal controls.

Primary Responsibilities:
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Execute and oversee the SEC reporting and accounting close processes (monthly/quarterly/annual), including preparing and reviewing journal entries and balance sheet reconciliations, as well as preparing full quarterly (Form 10-Q) and annual (Form 10-K) financial statements and notes to be filed with the SEC in an accurate and timely manner in accordance with US GAAP

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Ensure the consistent application, testing and documentation of internal controls in accordance with Sarbanes-Oxley requirement and in compliance with established policies and procedures

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Lead and mentor two direct reports including the Accounts Payable Manager and the Senior Accountant

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Ensure accurate expense recognition for accounting close, including R&D and clinical trial accruals, as well as stock-based compensation

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Review purchase orders and invoices in the intake-to-pay system in close coordination with the Procurement and Accounts Payable functions and T&E reports in the expense reporting system for accuracy, validity and compliance with established policies and procedures

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Manage accounts payable operations and activities, as well as the cash management and treasury functions including accounting for the Company’s investments in US Treasury securities

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Effect other SEC filings as needed (Form 8-K, Form DEF 14A, Registration Statement on Form S-8, etc.)

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Prepare and file local quarterly and annual tax returns including New York Sales and Use Tax and New York City Commercial Rent Tax

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Partner with and serve as the main contact for external auditors regarding quarterly reviews and annual audits

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Work closely with the Company’s Payroll and Equity Administration, Human Resource, and Legal functions to maintain accurate payroll and equity records

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Coordinate with internal stakeholders regarding costs and activities incurred on various contracts; prepare ad hoc analyses as requested

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Manage the Accounting department budgeting process and coordinate with FP&A as needed on the company-wide budget to actual process

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Maintain working relationships across the Company’s R&D and G&A teams

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Seek out opportunities for continuous improvement in the Accounting function, including the application of new software and Artificial Intelligence

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Other duties as assigned

Required Skills and Qualifications:
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Bachelor’s degree in Accounting or related field; CPA preferred

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10+ years of progressive accounting experience in the biotechnology industry (8+ years with a Graduate degree)

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Public accounting experience at a Big 4 firm preferred

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Robust understanding of and experience with:

(i) SEC reporting including financial statement preparation and disclosures, Sarbanes-Oxley internal controls compliance, and monthly/quarterly/annual accounting close processes;

(ii) US GAAP including accrual-based accounting and accounting for stock-based compensation (preferably at a public biotech company);

(iii) ERP and intake-to-pay systems (preferably NetSuite and Zip).

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Advanced Excel skills (modeling, pivot tables, VLOOKUPs)

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Prior experience mentoring and leading teams

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Proven ability to work independently while influencing others

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Experience operating in an ever-changing environment

About Lexeo

Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich’s Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.

Our work culture is a hybrid model with 2 days/week in the New York City office and 3 days working from home.

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.