Associate Director, Computational Development

At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a purpose driven environment. This is what we call the Veracyte way – it’s about how we work together, guided by our values, to give clinicians the insights they need to help patients make life-changing decisions.

Our Values:

• We Seek A Better Way: We innovate boldly, learn from our setbacks, and are resilient in our pursuit to transform cancer care

• We Make It Happen: We act with urgency, commit to quality, and bring fun to our hard work

• We Are Stronger Together: We collaborate openly, seek to understand, and celebrate our wins

• We Care Deeply: We embrace our differences, do the right thing, and encourage each other

The Position:

We are seeking a highly experienced and motivated Associate Director to lead the bioinformatics strategy, design, and development of next‑generation minimal residual disease (MRD) laboratory‑developed tests (LDTs). This role involves technical leadership and mentorship of computational development scientists as well as cross‑program coordination, based on deep hands‑on expertise in NGS ctDNA-based oncology assay development.

The Assistant Director will lead bioinformatics strategy across MRD assay programs, partnering closely with wet‑lab, clinical, quality, regulatory, and software teams to ensure delivery of analytically robust, clinically meaningful diagnostics under CAP/CLIA regulations and design control. This role is ideal for a senior scientist who remains deeply technical while beginning to operate at a program‑ and portfolio‑level.

KEY RESPONSIBILITIES:

Scientific & Technical Leadership

• Provide bioinformatics leadership for MRD assay design, development, and optimization across one or more LDT programs, ensuring alignment with scientific, clinical, and business objectives.

• Serve as a senior scientific contributor and reviewer for assay concepts, signal detection strategies, error suppression approaches, and MRD calling methodologies.

• Apply deep expertise in cancer genomics, ctDNA biology, and NGS technologies to guide assay architecture and analytical decision‑making

Assay Development & Validation

• Lead and/or oversee analytical study design and data analysis for assay development and validation, including accuracy, limit of detection, precision, and robustness.

• Guide development, validation, and maintenance of scalable, production‑ready bioinformatics pipelines supporting MRD analysis, QC, and reporting.

• Review and approve analytical approaches, benchmarking studies, and optimization strategies, ensuring scientific rigor and regulatory readiness.

• Ensure compliance with standards (CAP/CLIA, FDA, IVDR) throughout the bioinformatics development lifecycle, including rigorous testing and documentation.

Leadership & Influence

• Provide day‑to‑day scientific mentorship and technical guidance to bioinformatics scientists and senior scientists.

• Support career development of team members through coaching, technical review, and knowledge sharing.

• Communicate complex analytical concepts clearly to stakeholders at varying levels of technical depth, including senior leadership.

Who You Are:

REQUIRED EXPERIENCE:

• Ph.D. in Bioinformatics, Computational Biology, Genomics, Biostatistics, or a closely related quantitative field.

• Minimum 8 years of total relevant experience, with at least 5 years of management experience in biotech, diagnostics, or regulated healthcare environments.

• Demonstrated experience leading NGS‑based assay development for clinical diagnostics. Hands‑on experience with ctDNA‑based MRD assays, including personalized or tumor‑informed approaches.

• Strong programming skills in Python, with experience developing and benchmarking reproducible, production‑grade analysis pipelines, including experience with SDLC best practices.

• Proven experience working in design‑controlled, regulated environments (CAP/CLIA LDT, IVD, or equivalent) is a must.

• Track record of working with wet lab scientists on iterative experiment design, execution, analysis, and interpretation as a tightly integrated team.

• Demonstrated record of technical and scientific leadership, ownership, and independent work.

PREFERRED EXPERIENCE:

• Experience developing and deploying bioinformatics workflows in AWS (e.g., EC2, S3, Step Functions, Batch, Lambda, etc.).

• Strong understanding of germline and somatic mutation processes leading to complex variation and genome-wide biomarkers with potential clinical utility.

• Working knowledge of R.

• Experience with relational and non-relational database technologies is a plus.

#LI-Onsite, #LI-Hybrid, or #LI-Remote

For candidates based in our San Diego office, the salary (or hourly range is $202,000- $219,000.

For candidates based in our South San Francisco office, the salary or hourly range is $220,000 - $231,000.

For candidates working remote (US), the salary or hourly range is $192,000 - $208,000.

The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to years of experience, skillset, geographic location, industry, education, etc. Base pay is one part of the Total Package that is provided to compensate and recognize employees for their work, and this role may be eligible for additional discretionary bonuses/incentives, and restricted stock units.

Pay range
$192,000—$208,000 USD

What We Can Offer You

Veracyte is a growing company that offers significant career opportunities if you are curious, driven, patient-oriented and aspire to help us build a great company. We offer competitive compensation and benefits, and are committed to fostering an inclusive workforce, where diverse backgrounds are represented, engaged, and empowered to drive innovative ideas and decisions. We are thrilled to be recognized as a 2024 Certified™ Great Place to Work® in both the US and Israel - a testament to our dynamic, inclusive, and inspiring workplace where passion meets purpose.

About Veracyte

Veracyte (Nasdaq: VCYT) is a global diagnostics company whose vision is to transform cancer care for patients all over the world. We empower clinicians with the high-value insights they need to guide and assure patients at pivotal moments in the race to diagnose and treat cancer. Our Veracyte Diagnostics Platform delivers high-performing cancer tests that are fueled by broad genomic and clinical data, deep bioinformatic and AI capabilities, and a powerful evidence-generation engine, which ultimately drives durable reimbursement and guideline inclusion for our tests, along with new insights to support continued innovation and pipeline development. For more information, please visit www.veracyte.com or follow us on LinkedIn or X (Twitter).

Veracyte, Inc. is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability status. Veracyte participates in E-Verify in the United States. View our CCPA Disclosure Notice

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