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Administrative Assistant

Spyretherapeutics

US- Remote (U.S. Remote) Remote permanent

Posted: February 24, 2026

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Quick Summary

Provides administrative support to our Sr. Directors/Directors and Sr. Managers in a remote position.

Job Description

Spyre Therapeutics is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.

Role Summary:

We are seeking an experienced Administrative Assistant (AA) to provide administrative support to our Sr. Directors/Directors and Sr. Managers. The ideal candidate must have direct experience supporting Directors and Manager. Working 100% remotely, the AA must possess clear, concise communication, be a self-starter, who is proactive, prioritizes tasks and enjoys taking on new assignments. Being flexible, curious, detail-oriented, accountable, and willing to learn is essential.

Key Responsibilities:

• Provide administrative support for team members across the organization

• Schedule meetings to include both internal and external parties

• Coordinate and book international and domestic travel needs for team members

• Submit team expenses and credit card reconciliations in a timely manner and within our company’s policy

• Assist with meeting planning such as sourcing hotels, meeting space, conference registration and tracking tasks

• Assist with special projects such as all company events and offsites, onboarding/offboarding contractors and employees and contributing to our Admin SharePoint site

• Build strong cross-functional relationships and partner with other administrators to ensure a high functioning & collaborative admin team environment

Ideal Candidate:

• 2+ years’ related experience as an administrative assistant

• Bachelor’s degree and/or equivalent work experience

• Experience directly supporting Senior Directors/Directors, Sr. Managers/Managers is preferred

• Biotechnology industry strongly preferred

• Excellent communication skills, both written and verbal. Communicates clearly, concisely and in a highly professional and timely manner with all internal and external partners

• Experience managing and maintaining sensitive complex calendars of in-person, video, and external meetings across multiple global time zones, while working closely with teams and other EAs within the organization

• Exceptional time management and organizational skills with a strong attention to detail

• Proficient in Microsoft Office suite: Word, Excel, PowerPoint, Outlook& Teams with the ability to learn new programs, such as SharePoint, Forms, RAMP and Concur for T&E.

• Ability and willingness to travel up to 10%

What We Offer:

• Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.

• Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.

• Unlimited PTO

• Two, one-week company-wide shutdowns each

• Commitment to provide professional development opportunities.

• Remote working environment with frequent in-person meetings to address complex problems and build relationships.

The expected salary range offer for this role is $ 80,000 to $99,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.

As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.

Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.

Please also be aware that all job postings will be listed on our website at spyre.com/careers/.

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